Switching from GLP-1 injections to GLP-1 pills

At first, using GLP-1 medication for weight loss required an injection. Now, oral options that allow users to take a daily pill instead are also available. Maybe you don’t like shots or have had injection site reactions. Or you just think a pill suits your lifestyle better. There are many reasons why a person might want to switch from injections to oral medications. Here are a few things to keep in mind to ensure a smooth transition:  

Consult your healthcare team 

It is possible to switch from injection to pill. Your provider will help you determine if it’s a good switch for you. Once you make that decision, you'll have to figure out a schedule. For instance, the manufacturer recommends taking your first oral Wegovy pill one week after discontinuing the Wegovy injection. Other medications may work differently. Your healthcare team can help you strategize.  

Mind your timing 

For your injectable GLP-1, you were likely advised to take the shot at the same time of day each week. For some oral medications, timing is even more important. Be sure to check with your health care provider on what the restrictions are around timing on your pill. You may need to take it upon waking every day. If that’s the case, set an alarm or reminders to make it hard to miss it.  

Be careful with food  

Certain oral GLP-1 medications will need to be taken on an empty stomach with no more than 4 ounces of water only, with a 30-minute gap between the medication and any other food or beverage. This may not apply to all oral GLP-1 meds, however, so check with your pharmacist to be sure about yours.  

Consider other medications  

For pills like Wegovy, it’s important to wait at least 30 minutes before taking other oral medications. Talk to your healthcare provider or pharmacist to find out if this applies to your pill and strategize on the best time to take your other medications. 

Follow the instructions 

Manufacturers usually recommend that injectable GLP-1 medications are stored in the refrigerator. Oral meds, however, can be kept at room temperature. This should make life a bit easier, especially when it comes to travel.  

Monitor your symptoms 

Your healthcare provider is working with you to help you find the dose that’s right for you. If you notice any side effects, keep track of that information. The more you share with your provider, the better they can work with you to optimize your dose.  

Stay in touch with your team 

Your healthcare provider is there to help answer questions, give you useful tips, and adjust your routine as necessary. Being in regular contact with them can help you get the support you need for a successful transition to oral GLP-1 medication.