Preheat the oven to 425°F. Line a baking sheet with parchment paper and set aside.
Place cauliflower into the bowl of a food processor and pulse until finely ground. Transfer to a microwave-safe bowl. Cover loosely and place into the microwave for 4-5 minutes, or until softened. Let cool.
Using a clean dish towel or cheesecloth, drain cauliflower completely. Squeeze with the dish towel or cloth, removing as much water as possible.
Transfer cauliflower to a large bowl. Stir in eggs, mozzarella, Parmesan, oregano, salt, and garlic powder.
Pour mixture into the center of the baking sheet and spread into a circle, resembling a pizza crust. Bake for 20 minutes.
Add desired toppings and bake for an additional 10 minutes. Slice into 6 servings.
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